Jiménez-Jiménez F J, García-Ruiz P J, Molina J A
Department of Neurology, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, Spain.
Drug Saf. 1997 Mar;16(3):180-204. doi: 10.2165/00002018-199716030-00004.
Parkinsonism, tremor, chorea-ballismus, dystonia, tardive dyskinesia, myoclonus, tics and akathisia can be induced by many drugs. The drugs that are most frequently implicated in movement disorders are antipsychotics, calcium antagonists, orthopramides and substituted benzamides (e.g. metoclopramide, sulpiride, clebopride, domperidone), CNS stimulants, antidepressants, anticonvulsants, antiparkinsonian drugs and lithium. It is possible for a single drug to induce 2 or more types of movement disorders in the same patient. Movement disorders are not always reversible after drug withdrawal.
帕金森综合征、震颤、舞蹈手足徐动症、肌张力障碍、迟发性运动障碍、肌阵挛、抽搐和静坐不能可由多种药物诱发。最常与运动障碍相关的药物有抗精神病药、钙拮抗剂、邻苯二甲酰胺和取代苯甲酰胺（如甲氧氯普胺、舒必利、氯波必利、多潘立酮）、中枢神经系统兴奋剂、抗抑郁药、抗惊厥药、抗帕金森病药物和锂盐。同一种药物有可能在同一患者身上诱发两种或更多类型的运动障碍。停药后运动障碍并非总是可逆的。
