Merz E, Wellek S, Püttmann S, Bahlmann F, Weber G
Universitäts-Frauenklinik Mainz.
Ultraschall Med. 1995 Feb;16(1):12-7. doi: 10.1055/s-2007-1003230.
Aim of this study was to establish a growth model for the intrauterine growth of the following fetal parameters: orbital diameter, interorbital and biocular diameters.
Data were measured in a prospective cross-sectional study with real-time ultrasound. The study group consisted of 1090 healthy fetuses between 12 and 41 weeks gestation. For curve standardisation a growth model for all parameters was used.
Using this growth model growth profiles (5., 50., and 95. percentiles) were established. All orbital parameters showed a nonlinear growth.
Since ocular and orbital malformations (anophthalmia, microphthalmia, hypo- and hypertelorism) are often principal signs of generalised syndromes, orbital biometry is helpful for a detailed prenatal investigation of the fetal face. This is demonstrated in 2 cases with an orbital malformation (orbital hypoplasia, hypotelorism).
本研究的目的是建立以下胎儿参数宫内生长的生长模型：眶径、眶间径和双眼径。
在一项采用实时超声的前瞻性横断面研究中进行数据测量。研究组由1090例妊娠12至41周的健康胎儿组成。为进行曲线标准化，使用了所有参数的生长模型。
利用该生长模型建立了生长曲线（第5、第50和第95百分位数）。所有眼眶参数均呈非线性生长。
由于眼部和眼眶畸形（无眼、小眼、眼距过窄和过宽）通常是全身性综合征的主要体征，眼眶生物测量有助于对胎儿面部进行详细的产前检查。这在2例眼眶畸形（眼眶发育不全、眼距过窄）病例中得到了证实。
