How specific is the first recognition step of homologous recombination?
作者信息
Rao B J, Chiu S K, Bazemore L R, Reddy G, Radding C M
机构信息
Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA.
出版信息
Trends Biochem Sci. 1995 Mar;20(3):109-13. doi: 10.1016/s0968-0004(00)88976-8.
PMID:7709428
Abstract
The Escherichia coli RecA protein promotes homologous recognition in base triplets via non-Watson-Crick bonds that differ from those formed nonenzymically from DNA consisting of runs of purines or pyrimidines. Base substitutions reveal recognition to be permissive, consistent with a search for homology that achieves speed at the cost of precision.
摘要
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