Chang T H, Adachi H, Okuyama T, Mori N, Saito I, Zhang K Y, Sun X D, Li J M
Department of Pharmacology, China Medical University, Shenyang.
Zhongguo Yao Li Xue Bao. 1994 Nov;15(6):507-10.
Cardiohemodynamic effects of 3'-angeloyloxy-4'-acetoxy-3',4'-dihydroseselin (Pd-Ia) isolated from the Chinese medicinal plant Peucedanum praeruptorum Dunn were compared with those of diltiazem (Dil) in anesthetized open-chest dogs. Pd-Ia 3 mg.kg-1 increased coronary blood flow from 25 +/- 11 to 58 +/- 16 ml.min-1 (n = 7, P < 0.01) and decreased mean aortic pressure (MAP) from 13 +/- 2 to 8 +/- 1 kPa (P < 0.01), rate pressure product (RPP) from 1.9 +/- 0.5 to 1.3 +/- 0.3 MPa.bpm (P < 0.05), +dp/dtmax from 246 +/- 56 to 160 +/- 36 kPa.s-1 (P < 0.01) and systemic vascular resistance from 19 +/- 4 to 12 +/- 7 Pa.ml-1.min-1 (P < 0.05), together with an increase in HR. Dil showed effects similar to those of Pd-Ia except for a marked decrease in HR. The effects of Pd-Ia on MAP and RPP were approximately one-tenth as potent as those of Dil. The results demonstrated that Pd-Ia was a Ca2+ channel blocker.
将从中药白花前胡中分离得到的3'-当归酰氧基-4'-乙酰氧基-3',4'-二氢邪蒿内酯（Pd-Ia）与地尔硫䓬（Dil）在麻醉开胸犬身上的心脏血液动力学效应进行了比较。Pd-Ia 3 mg·kg-1可使冠状动脉血流量从25±11增加至58±16 ml·min-1（n = 7，P < 0.01），并使平均主动脉压（MAP）从13±2降至8±1 kPa（P < 0.01），心率血压乘积（RPP）从1.9±0.5降至1.3±0.3 MPa·bpm（P < 0.05），+dp/dtmax从246±56降至160±36 kPa·s-1（P < 0.01），全身血管阻力从19±4降至12±7 Pa·ml-1·min-1（P < 0.05），同时心率增加。除心率显著下降外，Dil显示出与Pd-Ia相似的效应。Pd-Ia对MAP和RPP的作用强度约为Dil的十分之一。结果表明Pd-Ia是一种钙通道阻滞剂。
