Lee L H, Baglin T P
Department of Haematology, Singapore General Hospital.
Ann Acad Med Singap. 1994 Nov;23(6 Suppl):77-83.
The production and regulation of components of haemostasis is largely dependent on liver function. Liver disease is associated with alteration of the coagulant:anticoagulant and fibrinolytic:antifibrinolytic balance as well as quantitative and qualitative alterations of the cellular components of haemostasis. In this article we have reviewed the nature and frequency of disturbed haemostatic function in patients with acute and chronic liver disease and during liver transplantation. The risk of haemorrhage and thrombosis, and mechanisms leading to these complications are reviewed and treatment strategies utilising blood component therapy and pharmacological manipulation of the coagulant and fibrinolytic systems are proposed. Finally, areas for further study are suggested so that rational effective therapeutic strategies can be developed.
止血成分的产生和调节在很大程度上依赖于肝功能。肝脏疾病与凝血：抗凝和纤维蛋白溶解：抗纤维蛋白溶解平衡的改变以及止血细胞成分的数量和质量改变有关。在本文中，我们回顾了急性和慢性肝病患者以及肝移植期间止血功能紊乱的性质和频率。对出血和血栓形成的风险以及导致这些并发症的机制进行了综述，并提出了利用血液成分疗法以及对凝血和纤维蛋白溶解系统进行药理学调控的治疗策略。最后，提出了进一步研究的领域，以便制定合理有效的治疗策略。
