Lasker M R, Eddleman K, Toor A H
Department of Pediatrics, Mount Sinai Medical Center, New York, New York, USA.
Am J Perinatol. 1995 Jan;12(1):14-7. doi: 10.1055/s-2007-994390.
The management of hemolytic disease has undergone a number of significant changes over the past few decades. Intrauterine transfusion therapy, particularly intravascular transfusions, have significantly reduced the morbidity and mortality associated with isoimmunization. This therapy results not only in the transfusion of blood, but also in the transfusion of iron. The long-term consequences of iron loading in the fetus are unknown. We report a case of a newborn with Rh hemolytic disease who was treated with in utero transfusions and subsequently developed liver disease consistent with iron overload.
在过去几十年中，溶血性疾病的治疗发生了许多重大变化。宫内输血疗法，尤其是血管内输血，已显著降低了与同种免疫相关的发病率和死亡率。这种疗法不仅导致血液的输注，还导致铁的输注。胎儿铁负荷的长期后果尚不清楚。我们报告了一例患有Rh溶血性疾病的新生儿，该患儿接受了宫内输血治疗，随后出现了与铁过载一致的肝病。
