Marshall J S, Bienenstock J
Department of Pathology and Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Curr Opin Immunol. 1994 Dec;6(6):853-9. doi: 10.1016/0952-7915(94)90004-3.
The concept that mast cells play a key role in the initiation of acute allergic responses has been around for many years. However, the role of mast cells in the chronic processes that are the hallmark of inflammatory disease is still poorly understood. With better techniques to study mast cell function it has become clear that these cells may have a much wider role in immune responses and regulation than previously recognized. Exciting progress has been made over the past year in defining the breadth of mast cell functions in inflammation. Further studies are necessary to evaluate the in vivo significance of many of these findings.
肥大细胞在急性过敏反应起始中起关键作用这一概念已存在多年。然而，肥大细胞在作为炎症性疾病标志的慢性过程中的作用仍知之甚少。随着研究肥大细胞功能的技术不断改进，已明确这些细胞在免疫反应和调节中的作用可能比之前认为的更为广泛。在过去一年里，在确定肥大细胞在炎症中的功能广度方面取得了令人兴奋的进展。有必要进一步开展研究，以评估其中许多发现的体内意义。
