Pittman T, Kiburz J, Gabriel K, Steinhardt G, Williams D, Slater J
Division of Neurological Surgery, Cardinal Glennon Hospital, St. Louis, Mo 63104, USA.
Pediatr Neurosurg. 1995;22(2):96-100. doi: 10.1159/000120883.
We studied the prevalence of latex-specific IgE among the children in our myelomeningocele clinic and several groups of controls using skin tests, a commercially available ELISA and an in-house RAST. Thirty-nine of 83 (47%) children with myelomeningocele had antibodies directed against latex as did 6 of 40 (15.7%) chronically ill controls, 4 of 105 (3.8%) medical controls and 2 of 75 (2.7%) well controls. Within each study group the likelihood of a positive skin test increased with the number of operations the subject had undergone. Children with myelomeningocele were much more likely to have antibodies to latex than were chronically ill controls with similar surgical histories. A retrospective chart review of 18 years and a total of 646 operations disclosed only one episode of intraoperative anaphylaxis which appeared to be related to latex within our study group.
我们使用皮肤试验、一种市售酶联免疫吸附测定（ELISA）和一种内部放射性变应原吸附试验（RAST），研究了我们脊髓脊膜膨出诊所的儿童以及几组对照人群中乳胶特异性免疫球蛋白E（IgE）的患病率。83名脊髓脊膜膨出患儿中有39名（47%）有针对乳胶的抗体，40名慢性病对照者中有6名（15.7%）、105名医疗对照者中有4名（3.8%）、75名健康对照者中有2名（2.7%）有针对乳胶的抗体。在每个研究组中，皮肤试验呈阳性的可能性随受试者接受手术的次数增加而增加。与有相似手术史的慢性病对照者相比，脊髓脊膜膨出患儿更有可能有乳胶抗体。对18年共646例手术的回顾性病历审查发现，在我们的研究组中只有1例术中过敏反应似乎与乳胶有关。
