Simecková A, Zamrazil V, Cerovská J, Stolba P
Institute of Endocrinology, Prague, Czech Republic.
Endocr Regul. 1994 Dec;28(4):205-9.
We have examined 56 subjects with normal glucose tolerance (NGT), 33 with impaired glucose tolerance (IGT) and 15 diabetics type II (DM) by an oral glucose tolerance test with 75 g of glucose and in addition to glycemia and C-peptide we estimated also calcemia, magnesemia, ionized calcium level (plus corrected ionized calcium level) in all time intervals. The basal glycemia and C-peptide values were different in each examined group, while the magnesium values distinguished only the DM group from the others. The corrected Ca2+ in 60 min decreased significantly in DM, while after 120 min there were no differences in the values. Magnesemia in NGT decreased after 60 and 120 min, while by IGT and DM it rised in both such intervals. The difference between IGT and DM was highly significant. Our findings give evidence about the changes in the distribution of magnesium already at an early stage of decrease glucose tolerance. The importance of this finding for an early IGT diagnostics and its further classification still remains to be definitely evaluated.
我们通过口服75克葡萄糖耐量试验对56名糖耐量正常（NGT）受试者、33名糖耐量受损（IGT）受试者和15名II型糖尿病（DM）患者进行了检查，除血糖和C肽外，我们还在所有时间间隔内评估了血钙、血镁、离子钙水平（加上校正后的离子钙水平）。各检查组的基础血糖和C肽值不同，而血镁值仅将糖尿病组与其他组区分开来。糖尿病组60分钟时校正后的Ca2+显著下降，而120分钟后各值无差异。糖耐量正常组60分钟和120分钟后血镁下降，而糖耐量受损组和糖尿病组在这两个时间间隔内血镁均升高。糖耐量受损组和糖尿病组之间的差异非常显著。我们的研究结果表明，在糖耐量降低的早期阶段，镁的分布就已经发生了变化。这一发现对早期糖耐量受损诊断及其进一步分类的重要性仍有待明确评估。
