Zamrazil V, Simecková A, Vána V, Bednár J, Vondra K
Výzkumný ústav endokrinologický, Praha.
Vnitr Lek. 1990 Jun;36(6):531-6.
In a group of 58 subjects with a strictly defined glucose tolerance (38 normal--nGT, 10 impaired glucose tolerance--pGT, 10 type II diabetics treated by diet) the authors investigated the mutual relationship between changes in the blood sugar level and insulin serum level in relation changes of calcium, ionized calcium, magnesium and total proteins. In addition to expected differences in the native blood sugar level and insulinaemia, the authors found in pGT group in reduction of ionized calcium and magnesium on fasting. In the course of the oGTT in pGT group there is a rise of ionized calcium and magnesium and thus the changes, as compared with the initial value, differ significantly from changes in subjects with a normal glucose tolerance and in type II diabetics. The differences in the pattern total calcium are less marked, the changes of total protein did not differ. Evaluation of correlations revealed a only significant relationship between the change of ionized calcium and blood sugar level after 120 mins, in DM II. The findings suggest a different calcium and magnesium metabolism after a glucose load in subjects with an impaired glucose tolerance. It is not clear whether a cause of the disorder is involved or a possible compensatory mechanism. The clinical impact will have to be examined.
在一组58名具有严格定义的糖耐量的受试者中（38名糖耐量正常——nGT，10名糖耐量受损——pGT，10名接受饮食治疗的II型糖尿病患者），作者研究了血糖水平变化与胰岛素血清水平变化之间的相互关系，以及它们与钙、离子钙、镁和总蛋白变化的关系。除了空腹血糖水平和胰岛素血症存在预期差异外，作者还发现pGT组空腹时离子钙和镁降低。在pGT组的口服葡萄糖耐量试验（oGTT）过程中，离子钙和镁升高，因此与初始值相比，这些变化与糖耐量正常的受试者和II型糖尿病患者的变化有显著差异。总钙模式的差异不太明显，总蛋白的变化没有差异。相关性评估显示，在II型糖尿病患者中，120分钟后离子钙变化与血糖水平之间仅存在显著关系。研究结果表明，糖耐量受损的受试者在葡萄糖负荷后钙和镁代谢不同。尚不清楚是涉及紊乱的原因还是可能的代偿机制。其临床影响有待进一步研究。
