Chaushu S, Chaushu G, Garfunkel A, Slavin S, Or R, Yefenof E
Lautenberg Center for General and Tumor Immunology, Hebrew University, Hadassah School of Dental Medicine and Medicine, Jerusalem, Israel.
Bone Marrow Transplant. 1994 Dec;14(6):925-8.
Patients undergoing bone marrow transplantation (BMT) have decreased levels of salivary Ig over long periods of time. However, shortly after transplantation, a transient rise of Ig concentration in their saliva gland is detected. In order to trace the origin of this Ig, seven BM donors were immunized with tetanus toxoid (TT) 4-7 days prior to BMT harvesting. Four patients received BM from non-immunized donors. All but one of the patients had no detectable anti-TT IgA in their parotid saliva prior to BMT. Recipients of T cell-depleted BM from pre-immunized donors transiently displayed high titers of salivary anti-TT IgA 7-28 days after transplantation. No significant anti-TT IgA titers were detected in saliva of patients grafted with non-immunized BM. We conclude that antibody-producing cells activated in the donor are passively transferred with the BM to the recipient. IgA committed cells home to the mucosa-associated lymphoid tissues (MALT) and continue to secrete antibodies until senescence.
接受骨髓移植（BMT）的患者在很长一段时间内唾液免疫球蛋白（Ig）水平会降低。然而，在移植后不久，会检测到其唾液腺中Ig浓度出现短暂升高。为了追踪这种Ig的来源，在采集BMT骨髓前4 - 7天，对7名骨髓供体进行破伤风类毒素（TT）免疫。4名患者接受了来自未免疫供体的骨髓。除1名患者外，所有患者在BMT前腮腺唾液中均未检测到抗TT IgA。接受来自预先免疫供体的去除T细胞骨髓的受者在移植后7 - 28天短暂出现高滴度唾液抗TT IgA。接受未免疫骨髓移植的患者唾液中未检测到显著的抗TT IgA滴度。我们得出结论，供体中被激活的抗体产生细胞随骨髓被动转移至受者。产生IgA的细胞归巢至黏膜相关淋巴组织（MALT）并持续分泌抗体直至衰老。
