Norhagen G, Engström P E, Björkstrand B, Hammarström L, Smith C I, Ringdén O
Department of Immunology, Microbiology, Pathology and Infectious Diseases, Karolinska Institute, Huddinge University Hospital, Sweden.
Bone Marrow Transplant. 1994 Aug;14(2):229-34.
Significantly decreased levels of all classes Ig were found in saliva and serum of 85 patients before and up to 5 years after bone marrow transplantation (BMT). Salivary levels of IgG were increased before BMT in patients that died shortly after transplantation (p = 0.04). Significantly higher secretory IgA (sIgA) levels in saliva were noted in patients with malignant disorders than in those with non-malignant diseases, both before (p = 0.007) and after BMT (p = 0.011). Recipients of autologous marrow had higher levels of salivary sIgA before BMT than recipients of allogeneic bone marrow (p = 0.020). With increased BM cell dose at transplantation, lower levels of salivary IgG and albumin were found. Patients with cytomegalovirus infections after transplantation showed increased salivary IgG levels (p = 0.029). Individuals with chronic GVHD had less salivary IgM one year after BMT (median value 3.2 mg/l, p = 0.04) than those without chronic GVHD (median value 42.6 mg/l). All Ig classes in serum were decreased directly after BMT and later normalized. Salivary levels of all Ig classes except IgD fluctuated post-BMT.
在85例骨髓移植（BMT）患者的唾液和血清中，发现所有类别的免疫球蛋白（Ig）水平在移植前及移植后长达5年显著降低。移植后不久死亡的患者在BMT前唾液中IgG水平升高（p = 0.04）。恶性疾病患者唾液中分泌型IgA（sIgA）水平在BMT前（p = 0.007）和BMT后（p = 0.011）均显著高于非恶性疾病患者。自体骨髓移植受者在BMT前唾液sIgA水平高于同种异体骨髓移植受者（p = 0.020）。随着移植时骨髓细胞剂量增加，唾液中IgG和白蛋白水平降低。移植后发生巨细胞病毒感染的患者唾液IgG水平升高（p = 0.029）。慢性移植物抗宿主病（GVHD）患者在BMT后1年唾液中IgM水平（中位数3.2mg/L，p = 0.04）低于无慢性GVHD患者（中位数42.6mg/L）。BMT后血清中所有类别的Ig均直接降低，随后恢复正常。BMT后除IgD外所有类别的唾液Ig水平均有波动。
