Luckman S M
Laboratory of Neuroendocrinology, Babraham Institute, Cambridge, UK.
Brain Res. 1995 Jan 9;669(1):115-24. doi: 10.1016/0006-8993(94)01271-i.
Vaginocervical stimulation, that occurs during mating or with the birth of pups, is believed to induce specific sexual and maternal behaviours in the rat as well as stimulating a number of neuroendocrine responses including the secretion of oxytocin, prolactin and luteinizing hormone. Since the medial preoptic area has been implicated in the induction of maternal behaviour, the expression of the immediate-early gene product Fos was compared between non-pregnant, late pregnant and parturient rats. Although no difference was detected in the number of Fos-positive neuronal profiles in the preoptic area of non-pregnant and late-pregnant rats, a large increase was observed in the medial preoptic nucleus and the anteroventral periventricular region, as well as in the hypothalamic supraoptic nucleus, of parturient rats. Double labelling for Fos and tyrosine hydroxylase immunoreactivity in the brainstem of parturient rats showed the activation of catecholaminergic neurons in both the nucleus of the tractus solitarius and in the ventrolateral medulla that may form part of the afferent pathway from the uterus and cervix to the preoptic area and hypothalamus.
阴道-子宫颈刺激发生在交配过程中或幼崽出生时，据信它会在大鼠体内诱发特定的性行为和母性行为，同时刺激包括催产素、催乳素和促黄体生成素分泌在内的多种神经内分泌反应。由于内侧视前区与母性行为的诱发有关，因此对未怀孕、妊娠晚期和分娩期大鼠的即刻早期基因产物Fos的表达进行了比较。虽然在未怀孕和妊娠晚期大鼠的视前区中，Fos阳性神经元轮廓数量未检测到差异，但在分娩期大鼠的内侧视前核、室周前腹侧区以及下丘脑视上核中观察到大量增加。对分娩期大鼠脑干中Fos和酪氨酸羟化酶免疫反应性进行双重标记显示，孤束核和延髓腹外侧的儿茶酚胺能神经元被激活，这可能构成从子宫和子宫颈到视前区和下丘脑的传入通路的一部分。
