Jenkins R A, Temoshok L R, Virochsiri K
Henry M. Jackson Foundation for the Advancement of Military Medicine & Military Medical Consortium for Applied Retroviral Research, Rockville, MD, USA.
J Acquir Immune Defic Syndr Hum Retrovirol. 1995 May 1;9(1):36-42.
An anonymous cross-sectional paper-and-pencil survey was used to assess incentives and disincentives to participate in a Phase I preventive human immunodeficiency virus (HIV) vaccine trial in a potential Thai target population. A total of 255 persons employed in health care service and research settings completed questionnaires after attending informational briefings regarding the proposed vaccine product and the planned trial procedures. Willingness to participate was related to self-perceived benefits from joining a preventive vaccine trial, as well as to concerns about product safety and social discrimination that might result from participation. The distinction between positive results of enzyme-linked immunosorbent assay from vaccine administration and positivity from HIV infection was unclear for many participants. Men were more willing to participate than women, and there was a trend toward greater willingness to participate in those who were less educated. Preparations for preventive vaccine trials may be more successful if they emphasize personal benefits of trial participation, clearly address safety issues, and consider ways to prevent social discrimination against participants.
一项匿名的纸笔问卷调查被用于评估在泰国潜在目标人群中参与一期预防性人类免疫缺陷病毒（HIV）疫苗试验的激励因素和阻碍因素。共有255名受雇于医疗服务和研究机构的人员在参加了关于拟议疫苗产品和计划试验程序的信息通报会后完成了问卷调查。参与意愿与参与预防性疫苗试验的自我认知益处有关，也与对产品安全性以及参与可能导致的社会歧视的担忧有关。许多参与者不清楚疫苗接种后酶联免疫吸附测定的阳性结果与HIV感染阳性之间的区别。男性比女性更愿意参与，并且教育程度较低者参与意愿有更高的趋势。如果预防性疫苗试验的准备工作强调试验参与的个人益处、明确解决安全问题并考虑防止对参与者的社会歧视的方法，可能会更成功。
