Nelson M J, Seitz S P
El Du Pont de Nemours & Co, Wilmington.
Curr Opin Struct Biol. 1994 Dec;4(6):878-84. doi: 10.1016/0959-440x(94)90270-4.
Lipoxygenases are non-heme iron enzymes that catalyze the dioxygenation of polyunsaturated fatty acids, yielding hydroperoxides. The first crystal structures have recently been published, revealing an unusual iron site. There have also been substantial developments in the analysis of the kinetics of the reaction, including the observation of uniquely large primary deuterium isotope effects. Exploitation of these results should enable substantial progress in understanding what appears to be a complicated and fascinating chemical mechanism.
脂氧合酶是一类非血红素铁酶，可催化多不饱和脂肪酸的双加氧反应，生成氢过氧化物。最近已发表了其首个晶体结构，揭示了一个不同寻常的铁位点。在该反应动力学分析方面也有了重大进展，包括观察到独特的大一级氘同位素效应。利用这些结果应能在理解这一看似复杂且引人入胜的化学机制方面取得实质性进展。
