Domain movements in protein kinases.
作者信息
Cox S, Radzio-Andzelm E, Taylor S S
机构信息
Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla 92093-0654.
出版信息
Curr Opin Struct Biol. 1994 Dec;4(6):893-901. doi: 10.1016/0959-440x(94)90272-0.
PMID:7712293
Abstract
Structural studies of the catalytic subunit of the cAMP-dependent protein kinase, both by crystallographic methods and in solution, reveal two conformations. Crystal structures of several other protein kinases have also been solved in the past year. With this combined information we can begin to define mobile domains and subdomains within the conserved catalytic core.
摘要
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