蛋白激酶中的结构域运动
Domain movements in protein kinases.
作者信息
Cox S, Radzio-Andzelm E, Taylor S S
机构信息
Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla 92093-0654.
出版信息
Curr Opin Struct Biol. 1994 Dec;4(6):893-901. doi: 10.1016/0959-440x(94)90272-0.
PMID:7712293
Abstract
Structural studies of the catalytic subunit of the cAMP-dependent protein kinase, both by crystallographic methods and in solution, reveal two conformations. Crystal structures of several other protein kinases have also been solved in the past year. With this combined information we can begin to define mobile domains and subdomains within the conserved catalytic core.
摘要
通过晶体学方法和溶液研究对环磷酸腺苷（cAMP）依赖性蛋白激酶催化亚基的结构研究揭示了两种构象。在过去的一年里，其他几种蛋白激酶的晶体结构也已得到解析。有了这些综合信息，我们就可以开始在保守的催化核心内定义可移动的结构域和亚结构域。
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