Taylor S S, Radzio-Andzelm E, Knighton D R, Ten Eyck L F, Sowadski J M, Herberg F W, Yonemoto W, Zheng J
Department of Chemistry, University of California, San Diego.
Receptor. 1993 Fall;3(3):165-72.
The crystal structure of the catalytic subunit of cAMP-dependent protein kinase serves as a template for the catalytic core of all eukaryotic protein kinases. The various crystal structures are reviewed with particular emphasis on the numerous conserved residues that converge at the active site. The structures also reveal the importance of posttranslational modifications, including myristylation and phosphorylation.
环磷酸腺苷（cAMP）依赖性蛋白激酶催化亚基的晶体结构可作为所有真核蛋白激酶催化核心的模板。本文综述了各种晶体结构，特别强调了汇聚于活性位点的众多保守残基。这些结构还揭示了翻译后修饰的重要性，包括肉豆蔻酰化和磷酸化。
