环磷酸腺苷（cAMP）依赖性蛋白激酶催化亚基的晶体结构揭示了蛋白激酶家族的一般特征。
Crystal structures of the catalytic subunit of cAMP-dependent protein kinase reveal general features of the protein kinase family.
作者信息
Taylor S S, Radzio-Andzelm E, Knighton D R, Ten Eyck L F, Sowadski J M, Herberg F W, Yonemoto W, Zheng J
机构信息
Department of Chemistry, University of California, San Diego.
出版信息
Receptor. 1993 Fall;3(3):165-72.
PMID:8167567
Abstract
The crystal structure of the catalytic subunit of cAMP-dependent protein kinase serves as a template for the catalytic core of all eukaryotic protein kinases. The various crystal structures are reviewed with particular emphasis on the numerous conserved residues that converge at the active site. The structures also reveal the importance of posttranslational modifications, including myristylation and phosphorylation.
摘要
环磷酸腺苷（cAMP）依赖性蛋白激酶催化亚基的晶体结构可作为所有真核蛋白激酶催化核心的模板。本文综述了各种晶体结构，特别强调了汇聚于活性位点的众多保守残基。这些结构还揭示了翻译后修饰的重要性，包括肉豆蔻酰化和磷酸化。
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