链脲佐菌素和四氧嘧啶在伤口愈合受损的糖尿病模型中是类似的药物。
Streptozotocin and alloxan are comparable agents in the diabetic model of impaired wound healing.
作者信息
Covington D S, Xue H, Pizzini R, Lally K P, Andrassy R J
机构信息
Division of Pediatric Surgery, University of Texas Medical School, Houston.
出版信息
Diabetes Res. 1993;23(2):47-53.
This study compares the drugs Streptozotocin (STZ) and Alloxan (ALN) in the diabetic wound healing model to determine the effect of their diverse immunologic and metabolic activity upon wound collagen and collagenase. Levels of hydroxyproline (as a measure of collagen) and collagenase were determined in polytetrafluorethylene (PTFE) wound cylinders harvested from STZ and ALN-diabetic rats and nondiabetic controls on post-operative days 5, 10 and 20. Animals treated with STZ and ALN had significantly less hydroxyproline on day 5 compared to control rats (p < 0.05). However, no difference was noted on days 10 and 20 between these two agents and controls, or between STZ and ALN at any time in the experiment. Despite their markedly dissimilar side effects, we conclude that either drug is appropriate in the diabetic wound healing when determining wound collagen and collagenase activity in this setting.
本研究在糖尿病伤口愈合模型中比较了链脲佐菌素（STZ）和四氧嘧啶（ALN）这两种药物，以确定它们不同的免疫和代谢活性对伤口胶原蛋白和胶原酶的影响。在术后第5、10和20天，从STZ和ALN诱导的糖尿病大鼠以及非糖尿病对照大鼠获取的聚四氟乙烯（PTFE）伤口圆柱体中，测定羟脯氨酸（作为胶原蛋白的指标）和胶原酶的水平。与对照大鼠相比，接受STZ和ALN治疗的动物在第5天的羟脯氨酸含量显著更低（p < 0.05）。然而，在第10天和第20天，这两种药物与对照之间没有差异，并且在实验的任何时间，STZ和ALN之间也没有差异。尽管它们的副作用明显不同，但我们得出结论，在这种情况下测定伤口胶原蛋白和胶原酶活性时，这两种药物在糖尿病伤口愈合中都是合适的。
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