Duan T, Zhang Z J, Goecke C
Obstets and Gynecol Hospital, Shanghai Medical University.
Zhonghua Fu Chan Ke Za Zhi. 1994 Nov;29(11):642-4, 697.
Normal human vascular endothelial cells were cocultured with sera from pregnancy induced hypertension (PIH) patients. After staining it was found that sera from PIH patients could induce stress fibers production from the endothelial cells and which sometime destroy the integrity of normal monolayer structure of endothelium, thus result in endothelial damage. Sera from PIH patients could also induce intracellular adhesion molecules on the cell surface, thus result in the blood cells adhesion to vascular wall, and loss of endothelial cells from vascular wall under certain condition, thereby causing endothelial damage.
将正常人血管内皮细胞与妊娠高血压综合征（PIH）患者的血清进行共培养。染色后发现，PIH患者的血清可诱导内皮细胞产生应激纤维，有时还会破坏内皮正常单层结构的完整性，从而导致内皮损伤。PIH患者的血清还可诱导细胞表面细胞间黏附分子的产生，进而导致血细胞黏附于血管壁，并在一定条件下使血管壁内皮细胞脱落，从而引起内皮损伤。
