Gao S S
Third Affiliated Hospital, Third Military Medical College, Chongqing.
Zhonghua Fu Chan Ke Za Zhi. 1993 Nov;28(11):653-6, 700.
Plasma endothelin-1 (ET-1) and atrial natriuretic peptide (ANP) concentrations were determined in 83 cases, including 30 cases of PIH and 30 normal pregnant women during their third trimester, and 23 non-pregnant women as controls.
compared to the non-pregnant women and normal pregnant women in their late pregnancy, the concentrations of plasma ET-1 and ANP were significantly increased in patients with PIH; after administration of magnesium sulfate infusion, the decrease of ET-1 and ANP concentrations was statistically significant in PIH cases, while there was no change in normal late pregnancy. In PIH patients, the score index of PIH had significant positive correlation with the level of plasma ET-1 (r = 0.717, P < 0.01). There were also positive correlations between the mean arterial pressure and the level of plasma ET-1 in PIH, normal pregnant and non-pregnant women (r = 0.613, P < 0.01; r = 0.441, P < 0.05; r = 0.586, P < 0.01). We failed to find any association between the concentrations of ET-1 and ANP in all 3 groups (r = 0.247, r = 0.384, r = -0.227; P > 0.05).
ET-1 acts as an important physioregulatory factor of blood pressure, and its increase may be responsible for the development of PIH, and may serve as an indicator of the severity of PIH.
测定了83例患者的血浆内皮素-1（ET-1）和心房利钠肽（ANP）浓度，其中包括30例妊娠期高血压疾病（PIH）患者、30例孕晚期正常孕妇以及23例未孕女性作为对照。
与未孕女性和孕晚期正常孕妇相比，PIH患者血浆ET-1和ANP浓度显著升高；硫酸镁静脉滴注后，PIH患者ET-1和ANP浓度下降具有统计学意义，而孕晚期正常孕妇无变化。PIH患者中，PIH评分指数与血浆ET-1水平呈显著正相关（r = 0.717，P < 0.01）。PIH患者、正常孕妇和未孕女性的平均动脉压与血浆ET-1水平之间也存在正相关（r = 0.613，P < 0.01；r = 0.441，P < 0.05；r = 0.586，P < 0.01）。在所有3组中，我们未发现ET-1和ANP浓度之间存在任何关联（r = 0.247，r = 0.384，r = -0.227；P > 0.05）。
ET-1作为血压的重要生理调节因子，其升高可能与PIH的发生有关，并可作为PIH严重程度的指标。
