Meinhardt W, Lycklama à Nijeholt A A, Kropman R F, Vermeij P, Zwartendijk J
Department of Urology, University Hospital of Leiden, The Netherlands.
Eur Urol. 1994;26(4):319-21. doi: 10.1159/000475407.
evaluation of a self-injection program with a mixture of papaverine, phentolamine and prostaglandin E1 (PGE1).
a self-injection program for erectile dysfunction was started by 48 patients, using a 1-ml mixture of 4.5 mg papaverine, 0.2 mg phentolamine and 1.5 micrograms PGE1. Patients completed a questionnaire at 6 weeks and at 3 months and were followed at the Outpatients Department for an average of 1 year.
of these patients 25 had previous experience with 20 micrograms PGE1 for intracavernous use and 22 patients had previously used 30 mg papaverine with 1 mg phentolamine. None of these 3 self-injection drugs is obviously superior in its ability to induce erections. Priapism occurred twice on a total of 1,290 injections. After 1-year follow-up, 4 patients had developed problems with fibrosis of the corpora, 2 of whom had encountered this problem also in a previous self-injection program.
this triple mixture has the disadvantage of causing fibrosis and priapism in susceptible patients.
评估罂粟碱、酚妥拉明和前列腺素E1（PGE1）混合剂的自我注射方案。
48例患者开始采用一种用于勃起功能障碍的自我注射方案，使用含4.5毫克罂粟碱、0.2毫克酚妥拉明和1.5微克PGE1的1毫升混合剂。患者在6周和3个月时完成一份问卷，并在门诊部接受平均1年的随访。
这些患者中，25例曾有过海绵体内使用20微克PGE1的经历，22例曾使用过含30毫克罂粟碱和1毫克酚妥拉明的药物。这三种自我注射药物在诱导勃起的能力上均无明显优势。在总共1290次注射中发生了两次阴茎异常勃起。经过1年的随访，4例患者出现了海绵体纤维化问题，其中2例在之前的自我注射方案中也遇到过这个问题。
这种三联混合剂在易感患者中存在导致纤维化和阴茎异常勃起的缺点。
