Criddle D N, de Moura R S
Departamento de Farmacologia, Universidade do Estado do Rio de Janeiro, Brazil.
Eur J Pharmacol. 1995 Jan 16;272(2-3):293-6. doi: 10.1016/0014-2999(94)00706-d.
The mechanoinhibitory effects of two structurally dissimilar K+ channel openers, levcromakalim and P1060, and verapamil were compared in strips of human myometrium bathed in either K-PSS (normal Krebs solution) or Rb-PSS (K+ salts replaced by Rb+ equivalents). In Rb-PSS the effects of levcromakalim and P1060 on amplitude and frequency of spontaneous contractions were inhibited by more than 20- and 138-fold, respectively, whereas those of verapamil were unaltered. These results indicate that K+ channel openers possess Rb-sensitive and Rb-insensitive mechanoinhibitory actions on the human uterus, the former being more important in the effects of P1060 than levcromakalim.
在浸泡于钾离子磷酸盐缓冲盐水（正常的克雷布斯溶液）或铷离子磷酸盐缓冲盐水（钾盐被等量铷盐取代）中的人子宫肌条中，比较了两种结构不同的钾通道开放剂（利克罗卡利姆和P1060）以及维拉帕米的机械抑制作用。在铷离子磷酸盐缓冲盐水中，利克罗卡利姆和P1060对自发收缩的幅度和频率的影响分别被抑制了20倍以上和138倍以上，而维拉帕米的作用未改变。这些结果表明，钾通道开放剂对人子宫具有铷敏感和铷不敏感的机械抑制作用，前者在P1060的作用中比在利克罗卡利姆的作用中更重要。
