Morita S, Arima T, Matsuda M
Oita National Hospital, Japan.
J Clin Endocrinol Metab. 1995 Apr;80(4):1203-6. doi: 10.1210/jcem.80.4.7714090.
To clarify the involvement of polyclonal activation of autoimmune reaction in organ-specific autoimmune diseases, we investigated the prevalence of nonthyroid specific autoantibodies in 50 patients with autoimmune thyroid diseases (22 patients with Graves' disease and 28 with Hashimoto's disease) and in 50 age- and sex-matched controls. None of the 100 subjects had any clinical manifestations or laboratory data indicating any other immunological, infectious, hepatic, or malignant diseases. The prevalence of positive antibodies to nucleus, smooth muscle, and single-stranded DNA in the patients (26%, 36%, and 34%, respectively) was higher than that in the control group (8%, 4%, and 4%, respectively), although neither group was positive for autoantibodies against double-stranded DNA, extractable nuclear antigen, SS-A, SS-B, mitochondria, or rheumatoid factor. Furthermore, 66% of the patients had at least one autoantibody to nucleus, smooth muscle, or single-stranded DNA. In conclusion, patients with autoimmune thyroid diseases show high prevalence of autoantibody against not only thyroid-specific, but also nonthyroid-specific antigens. These results are consistent with the concept that immune reaction of patients with organ-specific autoimmune diseases may be polyclonally accelerated to the production of antibodies against both organ and nonorgan specific autoantigens.
为了阐明自身免疫反应的多克隆激活在器官特异性自身免疫性疾病中的作用，我们调查了50例自身免疫性甲状腺疾病患者（22例格雷夫斯病患者和28例桥本甲状腺炎患者）以及50例年龄和性别匹配的对照者中非甲状腺特异性自身抗体的流行情况。这100名受试者均无任何表明存在其他免疫性、感染性、肝脏或恶性疾病的临床表现或实验室数据。患者中抗核抗体、抗平滑肌抗体和抗单链DNA抗体的阳性率分别为26%、36%和34%，高于对照组（分别为8%、4%和4%），尽管两组中抗双链DNA抗体、可提取核抗原、SS - A、SS - B、线粒体抗体或类风湿因子均为阴性。此外，66%的患者至少有一种抗核、抗平滑肌或抗单链DNA抗体。总之，自身免疫性甲状腺疾病患者不仅对甲状腺特异性抗原，而且对非甲状腺特异性抗原的自身抗体流行率都很高。这些结果与以下概念一致，即器官特异性自身免疫性疾病患者的免疫反应可能会多克隆加速，从而产生针对器官特异性和非器官特异性自身抗原的抗体。
