Stolwijk A M, Reuvers M J, Hamilton C J, Jongbloet P H, Hollanders J M, Zielhuis G A
Department of Medical Informatics, Epidemiology and Statistics, University of Nijmegen, The Netherlands.
Hum Reprod. 1994 Dec;9(12):2300-5. doi: 10.1093/oxfordjournals.humrep.a138441.
Seasonal variation has been found in various reproductive outcomes. As known causes for reducing the rate of success of in-vitro fertilization (IVF) cannot explain all the variation in IVF results, we studied whether the season had any additional explanatory power. The study population consisted of 1126 women who were treated for the first time with IVF at the University Hospital in Nijmegen, The Netherlands, between 1987 and 1993. Only first IVF cycles were analysed. After adjusting for confounding by the age of the woman, type of infertility, indication for IVF and year of aspiration, some seasonal variation was observed in the fertilization rate, embryo quality, pregnancy rate and birth rate.
人们发现各种生殖结果存在季节性变化。由于已知的降低体外受精（IVF）成功率的原因无法解释IVF结果的所有差异，我们研究了季节是否具有额外的解释力。研究人群包括1987年至1993年间在荷兰奈梅亨大学医院首次接受IVF治疗的1126名女性。仅分析首次IVF周期。在对女性年龄、不孕类型、IVF指征和取卵年份进行混杂因素调整后，观察到受精率、胚胎质量、妊娠率和出生率存在一些季节性变化。
