Center for Reproductive Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Henan Provincial Obstetrical and Gynecological Diseases (Reproductive Medicine) Clinical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Reprod Biol Endocrinol. 2022 Aug 6;20(1):113. doi: 10.1186/s12958-022-00986-3.
To investigate whether seasonal variations and meteorological factors influence pregnancy outcomes in women undergoing in vitro fertilization-embryo transfer (IVF-ET) treatment.
Retrospective cohort study.
University-affiliated reproductive medical center.
Women aged < 35 years undergoing IVF from June 1, 2015, to June 1, 2019.
Cycles were divided into four groups according to the date of the beginning of ovulation induction: spring (659 cycles), summer (578 cycles), autumn (519 cycles), and winter (534 cycles).
The high-quality embryo rate was higher in autumn and winter than in cycles in which ovulation induction occurred in spring and summer (58.70% vs. 58.78% vs. 62.67% vs. 63.42%; P < 0.001). The results of linear regression analysis showed that the high-quality embryo rate was significantly correlated with the daily average temperature of ovulation induction (P = 0.037). The clinical pregnancy rates of cycles starting ovulation induction in spring, summer, and autumn were significantly higher than those starting in winter (70.71% vs. 73.18% vs. 70.13% vs. 65.17%; P = 0.031), while the biochemical pregnancy rate, early abortion rate, and live birth rate were not significantly different (P > 0.050). Multivariate logistic regression analysis showed significant seasonal variation in clinical pregnancy (OR = 1.643, 95% CI = 1.203-2.243; P = 0.002), and that a higher daily average temperature at the time of ovulation induction increased the clinical pregnancy rate (OR = 1.012, 95% CI = 1.001-1.022; P = 0.031).
In women younger than 35 years who undergo IVF treatment, the season and ambient temperature on the date of the beginning of ovulation induction may have an impact on embryo development and clinical pregnancy.
探讨季节变化和气象因素是否会影响体外受精-胚胎移植（IVF-ET）治疗中女性的妊娠结局。
回顾性队列研究。
大学附属医院生殖医学中心。
2015 年 6 月 1 日至 2019 年 6 月 1 日年龄<35 岁行 IVF 的女性。
根据排卵诱导开始日期将周期分为四组：春季（659 个周期）、夏季（578 个周期）、秋季（519 个周期）和冬季（534 个周期）。
秋季和冬季的优质胚胎率高于春季和夏季排卵诱导周期（58.70%比 58.78%比 62.67%比 63.42%；P<0.001）。线性回归分析结果显示，优质胚胎率与排卵诱导时的日平均温度显著相关（P=0.037）。春季、夏季和秋季开始排卵诱导的周期的临床妊娠率明显高于冬季开始排卵诱导的周期（70.71%比 73.18%比 70.13%比 65.17%；P=0.031），而生化妊娠率、早期流产率和活产率无显著差异（P>0.050）。多因素 logistic 回归分析显示，临床妊娠存在明显的季节性差异（OR=1.643，95%CI=1.203-2.243；P=0.002），排卵诱导时的日平均温度升高会提高临床妊娠率（OR=1.012，95%CI=1.001-1.022；P=0.031）。
在年龄<35 岁行 IVF 治疗的女性中，排卵诱导开始日期的季节和环境温度可能会影响胚胎发育和临床妊娠。
