Miettinen T, Tiitinen A, Koistinen R, Julkunen M, Seppälä M
Department I of Obstetrics and Gynaecology, Helsinki University Central Hospital, Finland.
Hum Reprod. 1994 Dec;9(12):2429-31. doi: 10.1093/oxfordjournals.humrep.a138464.
Previous studies suggest that, in pregnancies after in-vitro fertilization (IVF) and embryo transfer following pituitary down-regulation with a gonadotrophin-releasing hormone analogue (buserelin) and ovulation induction with human gonadotrophins, the serum placental protein 14 (PP14) concentration is lower than in normally conceived pregnancies. We studied serum PP14 concentrations in two groups of women: (i) in 17 infertile women whose pregnancy followed IVF and embryo transfer using buserelin (long protocol) and human menopausal gonadotrophin for ovulation induction; (ii) in 15 women whose pregnancy followed transfer of frozen-thawed embryos. Similar PP14 concentrations were found in both groups on days 9-10, 14-15 and 70-77 after human chorionic gonadotrophin administration (buserelin, IVF/embryo transfer) or spontaneous luteinizing hormone surge (frozen-thawed embryo transfer). Our results show that PP14 secretion is not compromised by pituitary down-regulation with buserelin in infertile women with functional ovaries.
先前的研究表明，在使用促性腺激素释放激素类似物（布舍瑞林）进行垂体降调节并用人促性腺激素诱导排卵后进行体外受精（IVF）和胚胎移植的妊娠中，血清胎盘蛋白14（PP14）浓度低于正常受孕的妊娠。我们研究了两组女性的血清PP14浓度：（i）17名不孕女性，其妊娠是在使用布舍瑞林（长方案）和人绝经期促性腺激素诱导排卵后进行IVF和胚胎移植；（ii）15名妊娠是在冻融胚胎移植后发生的女性。在给予人绒毛膜促性腺激素（布舍瑞林、IVF/胚胎移植）或自发促黄体生成素激增（冻融胚胎移植）后的第9 - 10天、14 - 15天和70 - 77天，两组中发现了相似的PP14浓度。我们的结果表明，在具有功能性卵巢的不孕女性中，布舍瑞林垂体降调节不会损害PP14的分泌。
