O'Leary S J, Tong Y C, Clark G M
Department of Otolaryngology, University of Melbourne, Parkville, Australia.
J Acoust Soc Am. 1995 Apr;97(4):2378-93. doi: 10.1121/1.412977.
In response to 100-ms duration electrical stimulation within the range 50-400 pulses per second (pps), and at 1.6- to 2.4-mA stimulus current, a range of poststimulus time histogram (PSTH) patterns were observed from dorsal cochlear nucleus (DCN) units, they were usually primarylike, onset or "negative response" and occasionally buildup or pauser patterns. It appeared that the excitatory and suppressive processes, also termed neural drives, in response to 2.5-pps electrical stimulation were the main determinants of DCN unit responses to 50- to 400-pps stimulation. This was demonstrated by a model of DCN responses to electrical stimulation of the auditory nerve. The neural drives required to model the PSTH patterns were (i) an excitatory process with a latency of < 5 ms, (ii) a second excitatory process latency of 4.5-10 ms, (iii) a long acting suppressive process with a latency of < 15 ms and a duration of > 70 ms, (iv) a short acting suppressive response with a latency of 2.5-3.7 ms and a duration usually < 5 ms, but always < 20, and (v) a drive contributing spontaneous activity to the unit. In addition to these processes which were observed at 2.5 pps, an additional, transient suppressive process was postulated to operate only at 50-400 pps. It was postulated that the PSTH patterns observed were due to differences in the strengths of these drives between units.
针对每秒50 - 400次脉冲（pps）范围内持续100毫秒的电刺激，以及1.6 - 2.4毫安的刺激电流，从蜗背侧核（DCN）神经元中观察到一系列刺激后时间直方图（PSTH）模式，它们通常类似初级模式、起始或“负反应”模式，偶尔也会出现增强或暂停模式。似乎响应2.5 pps电刺激时的兴奋和抑制过程（也称为神经驱动）是DCN神经元对50 - 400 pps刺激反应的主要决定因素。这通过DCN对听神经电刺激反应的模型得到了证明。模拟PSTH模式所需的神经驱动为：（i）潜伏期小于5毫秒的兴奋过程；（ii）潜伏期为4.5 - 10毫秒的第二个兴奋过程；（iii）潜伏期小于15毫秒、持续时间大于70毫秒的长效抑制过程；（iv）潜伏期为2.5 - 3.7毫秒、持续时间通常小于5毫秒但始终小于20毫秒的短效抑制反应；以及（v）为神经元贡献自发活动的驱动。除了在2.5 pps时观察到的这些过程外，还假设存在一个仅在50 - 400 pps时起作用的额外瞬态抑制过程。据推测，观察到的PSTH模式是由于这些驱动在神经元之间的强度差异所致。
