Hellström P M, Nilsson I, Svenberg T
Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden.
J Intern Med. 1995 Apr;237(4):395-402. doi: 10.1111/j.1365-2796.1995.tb01193.x.
Bile empties into the duodenum not only after a meal but also in the interdigestive state. In man, interdigestive biliary emptying is related to fasting motor activity, the migrating motor complex (MMC), in the stomach and small bowel and generally occurs during phase 2 preceding a gastroduodenal phase 3 activity (activity front). It seems that the main regulatory peptide to initiate phase 3 is motilin. During a period with 13 phase 3 activities of MMC, 18 episodes of gall-bladder emptying and 19 motilin peaks were observed. Such a peak of plasma motilin usually took place 25 +/- 11 min after onset of biliary emptying. In conclusion, data indicate that motilin is released to the circulation by the biliary output and induces phase 3 of MMC. The induced phase 3 propels bile acids along the gut to promote their absorption in the distal intestine. The choleretic action of recycling of bile acids may cause subsequent episodes of biliary emptying with motilin release by the action of the enterohepatic circulation of bile acids. In such a manner the MMC may be withheld as a recycling motility pattern.
胆汁不仅在进食后排入十二指肠，在消化间期也会如此。在人类中，消化间期胆汁排空与胃和小肠的空腹运动活动即移行性运动复合波（MMC）有关，通常发生在胃十二指肠3期活动（活动波峰）之前的2期。似乎启动3期的主要调节肽是胃动素。在MMC出现13次3期活动期间，观察到18次胆囊排空和19次胃动素峰值。血浆胃动素的这种峰值通常在胆汁排空开始后25±11分钟出现。总之，数据表明胃动素通过胆汁排出释放到循环中，并诱导MMC的3期。诱导的3期将胆汁酸沿肠道推进，以促进其在远端肠道的吸收。胆汁酸循环的利胆作用可能通过胆汁酸肝肠循环的作用导致随后的胆汁排空发作和胃动素释放。通过这种方式，MMC可能作为一种循环运动模式被保留。
