Qvist N, Oster-Jørgensen E, Pedersen S A, Rasmussen L, Hovendal C, Holst J J
Dept. of Surgical Gastroenterology, Odense University Hospital, Denmark.
Scand J Gastroenterol. 1995 Feb;30(2):122-7. doi: 10.3109/00365529509093249.
The relationship between each single period of gallbladder emptying during the migrating motor complex (MMC) cycle and changes in concentration of plasma motilin and serum bile acids is unknown.
The variations in the concentration of plasma motilin and serum bile acids in relation to interdigestive gallbladder motility and the MMCs was studied in nine healthy male volunteers. A method combining biliary scintigraphy (99mTc-labelled dimethyl-iminodiacetic acid) and continuous pressure recording from the antroduodenal region was used.
During 9 MMC cycles a total of 15 episodes of gallbladder emptying were observed with a median (range) duration of 25 min (15-45 min). Each episode of gallbladder emptying was followed by a steep increase in plasma motilin, reaching a median value of 30 pmol/l (13-43 pmol/l), corresponding to an increase of 18 pmol/l (4-33 pmol/l). The increase in plasma motilin started at the beginning of gallbladder emptying, but the peak value was not reached until a median of 20 min (10-45 min) later. Low plasma motilin concentrations were found between the emptying periods in cases with two or more emptying during the MMC cycle. The serum concentration of bile acids also showed a cyclic variation in relation to gallbladder motility. During periods of gallbladder emptying serum bile acid concentration had a median value of 1.78 mumol/l, as compared with a median value of 1.17 mumol/l during periods of gallbladder filling. This difference did not reach significance, however. In the pooled data from all subjects, a significant correlation (p < 0.01) between the serum concentration of bile acids and plasma concentration of motilin was found.
Gallbladder emptying was followed by a steep increase in plasma motilin concentration, and in cases of two or more emptying periods during the MMC cycle the concentration decreased in between. The shape of the serum bile acid profile is dependent on the intestinal transport and absorption of bile acids, and the significance of the cyclic variation in serum concentration of bile acids in relation to plasma motilin, gallbladder motility, and MMC needs further investigation.
移行性运动复合波（MMC）周期中胆囊排空的各个时段与血浆胃动素浓度及血清胆汁酸变化之间的关系尚不清楚。
对9名健康男性志愿者研究了与消化间期胆囊运动及MMC相关的血浆胃动素浓度和血清胆汁酸浓度的变化。采用了一种将胆道闪烁显像（99mTc标记的二甲基亚氨基二乙酸）和十二指肠区域连续压力记录相结合的方法。
在9个MMC周期中，共观察到15次胆囊排空事件，中位（范围）持续时间为25分钟（15 - 45分钟）。每次胆囊排空事件后，血浆胃动素急剧升高，中位值达到30 pmol/l（13 - 43 pmol/l），相当于升高18 pmol/l（4 - 33 pmol/l）。血浆胃动素的升高始于胆囊排空开始时，但直到中位20分钟（10 - 45分钟）后才达到峰值。在MMC周期中有两次或更多次排空的情况下，排空期之间血浆胃动素浓度较低。血清胆汁酸浓度也显示出与胆囊运动相关的周期性变化。胆囊排空期血清胆汁酸浓度中位值为1.78 μmol/l，而胆囊充盈期中位值为1.17 μmol/l。然而，这种差异未达到显著水平。在所有受试者的汇总数据中，发现血清胆汁酸浓度与血浆胃动素浓度之间存在显著相关性（p < 0.01）。
胆囊排空后血浆胃动素浓度急剧升高，在MMC周期中有两次或更多次排空期的情况下，其间浓度降低。血清胆汁酸谱的形状取决于胆汁酸的肠道转运和吸收，血清胆汁酸浓度的周期性变化与血浆胃动素、胆囊运动及MMC之间关系的意义需要进一步研究。
