Combined chemoradiotherapy for locally advanced squamous cell carcinoma of the bulbomembranous urethra: a case report.

Patients with locally advanced squamous cell carcinoma of the bulbomembranous urethra fare poorly whether they undergo surgery or primary radiotherapy. Combined chemoradiotherapy has been used with encouraging results in the treatment of squamous cell carcinoma of the anal canal and esophagus, and limited reports suggest that this management may show promise in the control of squamous cell carcinoma of the urethra. We report good results in a man with locally advanced squamous cell carcinoma of the bulbomembranous urethra who underwent concomitant radiotherapy, mitomycin C and 5-fluorouracil. We encourage the use of this regimen in patients with urethral squamous cell carcinoma as well as the reporting of results.