van der Meulen M C, Carter D R
Rehabilitation Research & Developmental Center, Veterans Affairs Medical Center, Palo Alto, CA 94304, USA.
J Theor Biol. 1995 Feb 21;172(4):323-7. doi: 10.1006/jtbi.1995.0029.
Evolutionary and developmental factors responsible for the scaling relationships observed in animal skeletons are poorly understood. We have created a mathematical model for long bone cross-sectional development which incorporates both intrinsic growth and extrinsic, adaptive bone modeling in response to changes in bone mechanical strains during ontogeny. The model successfully simulates the developing morphology in individual animals and the bone geometric allometric relationships among adults across many species (range from mouse to elephant in size). Our results suggest that long bone scaling characteristics are not a result of intrinsic genetic factors but are the results of highly conserved, extrinsic biophysical processes whereby bone tissue strains modulate skeletal morphogenesis.
导致在动物骨骼中观察到的比例关系的进化和发育因素，目前还知之甚少。我们创建了一个长骨横截面发育的数学模型，该模型结合了内在生长以及外在的适应性骨建模，以响应个体发育过程中骨机械应变的变化。该模型成功模拟了个体动物的发育形态以及许多物种（大小范围从小鼠到大象）成年个体之间的骨几何异速生长关系。我们的结果表明，长骨比例特征不是内在遗传因素的结果，而是高度保守的外在生物物理过程的结果，即骨组织应变调节骨骼形态发生。
