Ozeretskovskaia N N, Sergiev V P
Med Parazitol (Mosk). 1994 Oct-Dec(4):9-14.
The hypersensitizing effect of benzimidazole carbamates (BC), the therapy for trichinellosis, especially in heavily infected patients, determines the necessity of simultaneous administration of glucocorticoids (GC) for the prevention of severe systemic and organ-specific complications. This combination delayed the convalescent period, in severe cases it provokes coagulopathic disorders, infrequently fatal haemorrhages. The combination of BC with nonsteroidal anti-inflammatory drugs (NSAIDs) significantly shortened the convalescent period in semisevere and moderate cases of the disease along with normalized PGF and PGE production. In experimental mice and guinea pigs, the inhibition of specific T-cell responses without inhibiting their response to FGA, and the high antibody mediated cytotoxic activity after BC and NSAID therapy were found. Thus, in severe cases of the disease GC should be applied very immediately, replaced later by NSAIDs. The possible role of the biological action of BC, as donors of imidazoles in the microenvironment of muscle larvae, favoured by the poor content of natural imidazoles is discussed.
苯并咪唑氨基甲酸酯（BC）是治疗旋毛虫病的药物，尤其是在重症感染患者中，其致敏作用决定了同时给予糖皮质激素（GC）以预防严重的全身和器官特异性并发症的必要性。这种联合用药延缓了恢复期，在严重病例中会引发凝血障碍，偶尔会导致致命性出血。在半重症和中度病例中，BC与非甾体抗炎药（NSAIDs）联合使用可显著缩短恢复期，同时使前列腺素F（PGF）和前列腺素E（PGE）的产生恢复正常。在实验小鼠和豚鼠中，发现BC和NSAID治疗后可抑制特异性T细胞反应而不抑制其对FGA的反应，并且具有高抗体介导的细胞毒活性。因此，在该疾病的严重病例中，应立即应用GC，随后用NSAIDs替代。文中讨论了BC作为咪唑供体在肌肉幼虫微环境中的生物学作用的可能作用，这一作用因天然咪唑含量低而得到促进。
