Klein C, Wenning G K, Quinn N P
University Department of Clinical Neurology, Institute of Neurology, Queen Square, London, UK.
Nervenarzt. 1995 Feb;66(2):133-5.
A 59-year-old man presented with an 18-month history of episodes of visual disturbance and dysphagia in association with gait unsteadiness and leg weakness lasting between 45 and 120 min. These episodes were interpreted as vertebrobasilar transitory ischemic attacks. However, they had been preceded by impotence for 6 months. Autonomic function tests remained normal until the age of 62 years when the patient developed documented orthostatic hypotension. Parkinsonism was precipitated by neuroleptic treatment at the age of 59 years, at which time pyramidal signs were evident. The patient was unable to tolerate levodopa preparations and subsequently developed the full clinical picture of pathologically proven multiple system atrophy, dying at age 65, 7 years after his first symptom.
一名59岁男性，有18个月的视力障碍和吞咽困难发作史，伴有步态不稳和腿部无力，持续45至120分钟。这些发作被解释为椎基底动脉短暂性脑缺血发作。然而，在此之前他已经出现了6个月的阳痿症状。自主神经功能测试一直正常，直到62岁时患者出现了记录在案的体位性低血压。59岁时因使用抗精神病药物诱发了帕金森综合征，当时锥体束征明显。患者无法耐受左旋多巴制剂，随后出现了经病理证实的多系统萎缩的完整临床表现，在首次出现症状7年后，于65岁时死亡。
