Schmidt J, Schmitt C, Hockwin O, Paulus U, von Bergmann K
Department of Experimental Ophthalmology, University of Bonn, Germany.
Ophthalmic Res. 1994;26(6):352-60. doi: 10.1159/000267501.
150 patients suffering from primary hypercholesterolemia were divided into three different groups receiving (1) lovastatin, (2) simvastatin, or (3) fenofibrate as controls. The aim of the study was to detect possible drug-induced ocular side effects, especially in the lens. The study period was 2 years. Ophthalmological examination and Scheimpflug photography were performed at the beginning and every 6 months. Increases or decreases in the visual acuity were distributed very similarly in the three groups. Definite evidence of side effects was not found, nor was there evidence of deleterious effects on refraction. The intraocular pressure revealed intraindividual fluctuations without clinical significance. Many changes were observed in the lens, all were minimal, including those of the extreme lens periphery which had no effect on visual acuity. The present study shows the great value of Scheimpflug photography with densitometric image analyses because of its objectivity when compared with other methods. Our observations provide good evidence that lovastatin and simvastatin have no undesirable toxic effects on the lens and other ocular tissues, compared with fenofibrate.
150名原发性高胆固醇血症患者被分为三组，分别接受（1）洛伐他汀、（2）辛伐他汀治疗，或（3）非诺贝特作为对照。该研究的目的是检测可能的药物性眼部副作用，尤其是晶状体方面的副作用。研究为期2年。在研究开始时及每6个月进行一次眼科检查和Scheimpflug摄影。三组患者视力的升高或降低分布非常相似。未发现明确的副作用证据，也没有对屈光有有害影响的证据。眼压显示个体内有波动，但无临床意义。在晶状体中观察到许多变化，所有变化都很微小，包括晶状体最周边的变化，这些变化对视力没有影响。本研究表明，与其他方法相比，Scheimpflug摄影结合密度图像分析具有很大价值，因为其具有客观性。我们的观察提供了充分证据，表明与非诺贝特相比，洛伐他汀和辛伐他汀对晶状体和其他眼部组织没有不良毒性作用。
