Di Simone N, De Carolis S, Lanzone A, Ronsisvalle E, Giannice R, Caruso A
Department of Obstetrics and Gynecology, Università Cattolica S. Cuore, Rome, Italy.
Placenta. 1995 Jan;16(1):75-83. doi: 10.1016/0143-4004(95)90083-7.
Our objective was to evaluate whether antiphospholipid antibody-containing sera could play a regulatory role in signal transduction induced by gonadotrophin releasing hormone (GnRH) when incubated with normal human trophoblast cells. To test this hypothesis we established an in vitro placental culture system in which GnRH addition in the presence of normal human serum resulted in a significant increase in human chorionic gonadotrophin (hCG) secretion. When GnRH was added to the culture medium with antiphospholipid antibody-containing sera, the hCG increase was inhibited. These results suggest the possibility that antiphospholipid antibody-positive sera can exert their effect on GnRH-induced signal transduction. Further studies are needed to explain their exact site of action.
我们的目的是评估含有抗磷脂抗体的血清在与正常人滋养层细胞一起孵育时，是否能在促性腺激素释放激素（GnRH）诱导的信号转导中发挥调节作用。为了验证这一假设，我们建立了一种体外胎盘培养系统，在该系统中，在正常人血清存在的情况下添加GnRH会导致人绒毛膜促性腺激素（hCG）分泌显著增加。当在含有抗磷脂抗体的血清的培养基中添加GnRH时，hCG的增加受到抑制。这些结果提示抗磷脂抗体阳性血清可能对GnRH诱导的信号转导产生影响。需要进一步研究以解释其确切作用位点。
