Miyasaka K, Funakoshi A
Department of Clinical Physiology, Tokyo Metropolitan Institute of Gerontology, Japan.
Pancreas. 1995 Mar;10(2):200-3. doi: 10.1097/00006676-199503000-00015.
Pancreatic exocrine secretion in conscious rats in regulated by bile and pancreatic juice in the proximal intestinal lumen; exclusion of bile and pancreatic juice produces release of cholecystokinin (CCK) and pancreatic hypersecretion (luminal feedback regulation). In the present study, we examined the changes of gene expressions of CCK and secretin, another representative gastrointestinal hormone in the intestine, and found that exclusion of bile and pancreatic juice significantly enhanced gene expressions of both CCK and secretin. These results suggested involvement of both CCK and secretin in luminal feedback regulation.
清醒大鼠的胰腺外分泌受近端肠腔内胆汁和胰液的调节；排除胆汁和胰液会导致胆囊收缩素（CCK）释放和胰腺分泌亢进（腔内反馈调节）。在本研究中，我们检测了CCK和促胰液素（肠道中另一种代表性胃肠激素）的基因表达变化，发现排除胆汁和胰液会显著增强CCK和促胰液素的基因表达。这些结果表明CCK和促胰液素均参与腔内反馈调节。
