Meguid R A, Beverly J L, Meguid M M
Surgical Metabolism and Nutrition Laboratory, University Hospital, SUNY Health Science Center, Syracuse 13210, USA.
Physiol Behav. 1995 Feb;57(2):265-9. doi: 10.1016/0031-9384(94)00244-y.
The relationship between surfeit caloric consumption during intravenous infusion of a parenteral nutrition solution providing 100% daily caloric needs (PN-100; glucose:fat:amino acid = 50:30:20), carcass adiposity, and postinfusion food intake was evaluated. Rats received saline (control) or PN-100 for 4 days via jugular vein. PN-100 rats were either allowed or denied access to chow during the infusion period. When food was available during the 4 days of PN-100, total cumulative caloric intake, eaten and infused, was 40% higher than controls (p < 0.01). Percent carcass adiposity was increased from 8.8% to 11.6% (p = 0.04), and there was a 3-day delay before food intake returned to baseline. When caloric intake was limited to that provided by PN-100, carcass adiposity was not increased and food intake was 86% of baseline during the first 24 h after stopping PN-100. Delayed return of normal food intake following PN-100 is the likely consequence of excess caloric ingestion during the PN-100 infusion period. The surfeit caloric intake resulted in increased carcass adiposity.
评估了在静脉输注提供每日100%热量需求的肠外营养溶液（PN - 100；葡萄糖:脂肪:氨基酸 = 50:30:20）期间过量热量摄入、胴体脂肪含量与输注后食物摄入量之间的关系。大鼠通过颈静脉接受生理盐水（对照）或PN - 100，持续4天。PN - 100组大鼠在输注期间要么可以进食，要么禁食。当在PN - 100的4天期间可以进食时，摄入和输注的总累积热量摄入量比对照组高40%（p < 0.01）。胴体脂肪百分比从8.8%增加到11.6%（p = 0.04），并且食物摄入量恢复到基线水平之前有3天的延迟。当热量摄入限制在PN - 100提供的量时，胴体脂肪含量没有增加，并且在停止PN - 100后的最初24小时内食物摄入量为基线水平的86%。PN - 100后正常食物摄入量的延迟恢复可能是PN - 100输注期间热量摄入过多的结果。过量的热量摄入导致胴体脂肪含量增加。
