Meguid M M, Beverly J L, Yang Z J, Gleason J R, Meguid R A, Yue M X
Department of Surgery, University Hospital, State University of New York Health Science Center, Syracuse 13210.
Am J Physiol. 1993 Dec;265(6 Pt 2):R1387-91. doi: 10.1152/ajpregu.1993.265.6.R1387.
To determine whether brain glycogen concentrations change during parenteral nutrition, Fischer 344 rats with jugular vein catheters received 0.9 N saline or parenteral nutrition providing 100% of daily calories (PN-100). Rats were killed after 4 days of PN-100 and serially after PN-100 was stopped. Food intake decreased during PN-100 to approximately 15% of control, but total kilocalories eaten and infused over the 4-day PN-100 period was approximately 130% of control. Food intake of PN-100 rats remained low for 3-4 days post-PN-100. At the end of the 4-day PN-100 period, plasma glucose and insulin (P = 0.01) and whole brain glycogen (P < 0.005) were higher than but similar to control within 24 h of PN-100 being stopped. When PN-100 rats were not allowed to eat during the infusion period, plasma glucose was lower, plasma insulin higher, and brain glycogen content the same as in control rats after 4 days of PN-100. The increased brain glycogen was the likely consequence of the hyperglycemia and hyperinsulinemia during PN-100 and was not causally associated with the reduced food intake either during or immediately after PN-100.
为了确定肠外营养期间脑糖原浓度是否会发生变化，给置有颈静脉导管的Fischer 344大鼠输注0.9N生理盐水或提供100%每日热量的肠外营养（PN - 100）。在PN - 100治疗4天后处死大鼠，并在停止PN - 100后连续处死。在PN - 100期间，食物摄入量降至对照组的约15%，但在4天的PN - 100期间摄入和输注的总千卡数约为对照组的130%。PN - 100大鼠在停止PN - 100后的3 - 4天内食物摄入量仍然较低。在4天的PN - 100期结束时，在停止PN - 100后的24小时内，血浆葡萄糖和胰岛素（P = 0.01）以及全脑糖原（P < 0.005）均高于对照组但与对照组相似。当PN - 100大鼠在输注期间不允许进食时，在PN - 100治疗4天后，血浆葡萄糖较低，血浆胰岛素较高，脑糖原含量与对照大鼠相同。脑糖原增加可能是PN - 100期间高血糖和高胰岛素血症的结果，并且与PN - 100期间或之后立即减少的食物摄入量没有因果关系。
