Fameli M, Kitraki E, Stylianopoulou F
Laboratory of Histology-Embryology, Athens University Medical School, Greece.
Physiol Behav. 1995 Feb;57(2):397-400. doi: 10.1016/0031-9384(94)00228-w.
Experimental female rats were injected with ACTH during the last third of their pregnancy. This treatment resulted in prolongation of gestation and in abnormal development of the young. The number of resorptions, stillbirths, and congenitally malformed pups was increased and those that appeared normal had lower body weights. The experimental treatment also severely affected the ability of the dams to exhibit normal maternal behavior. Significant individual differences were noted in the sensitivity of the dams to the experimental treatment. Cross-fostering experiments revealed that experimental dams exhibited normal maternal behavior towards control foster pups, after an initial delay of 24 h. When experimental pups, born after a prolonged gestation, or delivered by caesarian section after the normal duration of gestation, were given to control mothers, normal maternal behavior was observed, but the survival rate of the young was not increased.
在妊娠后期的三分之一阶段，对实验雌性大鼠注射促肾上腺皮质激素（ACTH）。这种处理导致妊娠期延长以及幼崽发育异常。吸收、死产和先天性畸形幼崽的数量增加，而那些看似正常的幼崽体重较低。实验处理还严重影响了母鼠表现出正常母性行为的能力。母鼠对实验处理的敏感性存在显著的个体差异。交叉寄养实验表明，实验母鼠在最初延迟24小时后，对对照寄养幼崽表现出正常的母性行为。当将妊娠期延长后出生的实验幼崽，或在正常妊娠期后通过剖腹产分娩的幼崽交给对照母鼠时，观察到正常的母性行为，但幼崽的存活率并未提高。
