Sircar S, Lahiri P
Department of Zoology, University of Calcutta, India.
Toxicology. 1989 Dec 1;59(2):171-7. doi: 10.1016/0300-483x(89)90055-3.
Lindane (gamma-Hexachlorocyclohexane) was orally given to pregnant Swiss female mice at various stages of pregnancy. During early pregnancy (1-4 days of gestation), the insecticide caused total absence of any implantation site, while given during mid pregnancy (6-12 days of gestation), lindane caused total resorption of fetuses. Lindane administration during late pregnancy (14-19 days of gestation) resulted in death of all pups either within 12 h (high-dosed group) or 5 days (low-dosed group) of parturition. Body weight of such pups were also highly reduced. When estrogen was given together with lindane at early pregnancy, implantation was normal, although subsequent fetal development was adversely affected. Progesterone, unlike estrogen, could not correct lindane-induced failure in implantation. On the other hand, when estrogen and progesterone were simultaneously given to lindane-fed mice during early pregnancy, both implantation and subsequent fetal development became comparable to normal mice. The insecticide besides being fetotoxic, thus appears to cause steroid hormone deficiency resulting in reproductive and developmental failure.
在妊娠的不同阶段，将林丹（γ-六氯环己烷）经口给予怀孕的瑞士雌性小鼠。在妊娠早期（妊娠第1 - 4天）给予该杀虫剂，会导致完全没有任何着床部位；而在妊娠中期（妊娠第6 - 12天）给予林丹，会导致胎儿完全吸收。在妊娠晚期（妊娠第14 - 19天）给予林丹，会导致所有幼崽在分娩后12小时内（高剂量组）或5天内（低剂量组）死亡。这些幼崽的体重也显著降低。当在妊娠早期将雌激素与林丹一起给予时，着床正常，尽管随后的胎儿发育受到不利影响。与雌激素不同，孕酮不能纠正林丹诱导的着床失败。另一方面，当在妊娠早期同时将雌激素和孕酮给予喂食林丹的小鼠时，着床和随后的胎儿发育都变得与正常小鼠相当。因此，这种杀虫剂除了具有胚胎毒性外，似乎还会导致甾体激素缺乏，从而导致生殖和发育失败。
