Sessa M, Della Sala M, Bianchi D, Stanà C, Tamburrini O, Irrera G, Messina G
Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Reggio Calabria.
Radiol Med. 1995 Jan-Feb;89(1-2):130-5.
Aplastic anemia is a rare hematologic disorder characterized by hypocellular fatty marrow. Aplastic anemia is diagnosed on the basis of laboratory tests and bone marrow biopsy findings. Biopsy is of fundamental importance for bone marrow assessment, though not representative of the rest of the marrow. Thanks to its exclusive capabilities in the direct visualization of bone marrow, MRI is a noninvasive and relatively rapid method for bone marrow study. The authors report their experience in 3 aplastic anemia patients examined also with MRI at presentation and after marrow transplantation. The dorsolumbar spine was studied with sagittal SE T1-weighted and STIR sequences, while pelvic bones were investigated only with SE T1-weighted sequences in all patients. Two of them were also examined with sagittal scans of the dorsolumbar spine using the chemical shift fat suppression technique. In all three patients, SE T1-weighted images at presentation showed fatty bone marrow infiltration, also confirmed on fat suppression images, and, after transplantation, progressive bone marrow repopulation, with the typical "band" pattern in vertebral marrow. Although MR specificity remains low in the demonstration of bone marrow disorders, the authors believe it to be a useful tool, after accurate clinical and laboratory exams, not only in the diagnosis but also and especially in the follow-up of these disorders.
再生障碍性贫血是一种罕见的血液系统疾病，其特征为骨髓细胞减少伴脂肪化。再生障碍性贫血是根据实验室检查和骨髓活检结果进行诊断的。活检对于骨髓评估至关重要，尽管它并不代表其余骨髓的情况。由于MRI在直接观察骨髓方面具有独特能力，它是一种用于骨髓研究的非侵入性且相对快速的方法。作者报告了他们对3例再生障碍性贫血患者的经验，这些患者在就诊时以及骨髓移植后均接受了MRI检查。所有患者均采用矢状位SE T1加权和STIR序列对胸腰椎进行检查，而骨盆骨仅采用SE T1加权序列进行检查。其中2例患者还采用化学位移脂肪抑制技术对胸腰椎进行矢状位扫描。在所有3例患者中，就诊时的SE T1加权图像显示脂肪骨髓浸润，脂肪抑制图像也证实了这一点，移植后骨髓逐渐重新填充，椎体骨髓出现典型的“带状”模式。尽管MRI在显示骨髓疾病方面的特异性仍然较低，但作者认为，在进行准确的临床和实验室检查后，它不仅是诊断这些疾病的有用工具，而且在这些疾病的随访中尤其有用。
