三七总皂苷对血管平滑肌中受体操纵性钙通道的影响。
Effects of Panax notoginseng saponins on receptor-operated Ca2+ channels in vascular smooth muscle.
作者信息
Guan Y Y, Kwan C Y, He H, Sun J J, Daniel E E
机构信息
Department of Pharmacology, Sun Yat-Sen University of Medical Sciences, Guangzhou.
出版信息
Zhongguo Yao Li Xue Bao. 1994 Sep;15(5):392-8.
The effects of saponins of Panax notoginseng (PNGS) on the alpha-adrenoceptor agonists-induced contractile responses and Ca2+ movement were studied in dog mesenteric artery (MA) and saphenous vein (SV). PNGS reduced the contractions and the 45Ca influx (from 0.36 +/- 0.03 to 0.14 +/- 0.05 mumol.g-1 wet strip) induced by phenylephrine (Phe) without effect on KCl-induced contraction and 45Ca influx which were nearly completely inhibited by nifedipine 0.1 mumol.L-1. PNGS did not change the 45Ca efflux induced by Phe and the Kd value (from 0.76 +/- 0.04 to 0.72 +/- 0.15 nmol.L-1) for [3H]prazosin binding on the microsomal membrane isolated from MA. Our results indicate that PNGS selectively inhibits Ca2+ entry through receptor-operated Ca2+ channel.
研究了三七总皂苷（PNGS）对犬肠系膜动脉（MA）和隐静脉（SV）中α-肾上腺素能受体激动剂诱导的收缩反应及Ca2+运动的影响。PNGS可减弱去氧肾上腺素（Phe）诱导的收缩及45Ca内流（从0.36±0.03降至0.14±0.05μmol·g-1湿条），而对KCl诱导的收缩及45Ca内流无影响，后者几乎完全被0.1μmol·L-1硝苯地平抑制。PNGS不改变Phe诱导的45Ca外流及MA分离的微粒体膜上[3H]哌唑嗪结合的Kd值（从0.76±0.04降至0.72±0.15nmol·L-1）。我们的结果表明，PNGS可选择性抑制通过受体操纵性Ca2+通道的Ca2+内流。
Zotero 插件