西洋参提取物在空间学习任务中可减轻东莨菪碱诱导的记忆缺失。
American ginseng extract reduces scopolamine-induced amnesia in a spatial learning task.
作者信息
Sloley B D, Pang P K, Huang B H, Ba F, Li F L, Benishin C G, Greenshaw A J, Shan J J
机构信息
CV Technologies, Edmonton, Alta.
出版信息
J Psychiatry Neurosci. 1999 Nov;24(5):442-52.
OBJECTIVE
To determine if HT-1001, an extract of American ginseng, affects scopolamine-induced memory and performance deficits in a spatial learning task, alters brain concentrations of aminergic neurotransmitters, and alters choline uptake in synaptosome preparations.
DESIGN
Animal study.
ANIMALS
48 Sprague Dawley rats.
INTERVENTIONS
Long-term oral administration of a test material or control solution. Intraperitoneal administration of scopolamine (2 mg/kg) 30 minutes before testing.
OUTCOME MEASURES
Performance on Morris water maze task, choline uptake, aminergic neurotransmitter analysis, in vitro monoamine oxidase analysis (of compounds).
RESULTS
HT-1001 protected against scopolamine-induced amnesia and increased choline uptake in synaptosomal preparations. HT-1001 did not alter brain concentrations of norepinephrine, dopamine, 5-HT (serotonin), 3,4-dihydroxyphenylacetic acid or 5-hydroxyindoleactic acid. HT-1001 had a very weak ability to inhibit monoamine oxidase activity in vitro.
CONCLUSIONS
HT-1001 demonstrates a capacity to protect against scopolamine-induced memory deficits.
目的
确定人参提取物HT - 1001是否会影响东莨菪碱诱导的空间学习任务中的记忆和行为缺陷，改变大脑中胺能神经递质的浓度，以及改变突触体制剂中的胆碱摄取。
设计
动物研究。
动物
48只斯普拉格 - 道利大鼠。
干预措施
长期口服测试材料或对照溶液。在测试前30分钟腹腔注射东莨菪碱（2毫克/千克）。
观察指标
莫里斯水迷宫任务表现、胆碱摄取、胺能神经递质分析、体外单胺氧化酶分析（化合物）。
结果
HT - 1001可预防东莨菪碱诱导的失忆，并增加突触体制剂中的胆碱摄取。HT - 1001并未改变大脑中去甲肾上腺素、多巴胺、5 - 羟色胺（血清素）、3,4 - 二羟基苯乙酸或5 - 羟基吲哚乙酸的浓度。HT - 1001在体外抑制单胺氧化酶活性的能力非常弱。
结论
HT - 1001显示出预防东莨菪碱诱导的记忆缺陷的能力。
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