Malczewska-Malec M, Goldsztajn P, Kawecka-Jaszcz K, Czarnecka D, Siedlecki A, Siemienska T, Dembinska-Kiec A
Department of Clinical Biochemistry, Collegium Medicum, Jagiellonian University, Krakow, Poland.
Agents Actions Suppl. 1995;45:157-62. doi: 10.1007/978-3-0348-7346-8_22.
L-arginine (L-Arg) was administered intravenously through 4 consecutive days to 20 males (40-63 years old) with essential hypertension (EH). Significant decrease (p < 0.02) of systolic blood pressure (SBP) was observed only during the first day of the therapy and tachyphylaxis against L-Arg was noticed. The reduction of diastolic blood pressure (DBP) was more marked (p < 0.001). Significant changes in cGMP plasma level and the nitrite/nitrate urine concentration were not observed. L-Arg caused a significant activation of fibrinolysis (p < 0.005). The decrease of platelet activity, measured by the ADP-induced aggregation, after L-Arg administration was not statistically significant. Therefore, L-Arg may play only a secondary role in the treatment of EH.
对20名年龄在40 - 63岁的原发性高血压（EH）男性患者连续4天静脉注射L - 精氨酸（L - Arg）。仅在治疗的第一天观察到收缩压（SBP）显著下降（p < 0.02），并且注意到对L - Arg产生了快速耐受性。舒张压（DBP）的降低更为明显（p < 0.001）。未观察到血浆cGMP水平和尿中亚硝酸盐/硝酸盐浓度的显著变化。L - Arg引起纤维蛋白溶解显著激活（p < 0.005）。L - Arg给药后，通过ADP诱导的聚集测量的血小板活性降低无统计学意义。因此，L - Arg在EH治疗中可能仅起次要作用。
