Hishikawa K, Nakaki T, Suzuki H, Kato R, Saruta T
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
J Cardiovasc Pharmacol. 1992;20 Suppl 12:S196-7. doi: 10.1097/00005344-199204002-00055.
L-Arginine, the precursor of endothelium-derived relaxing factor (EDRF)/nitric oxide (NO), was administered intravenously in five patients with essential hypertension, one with renovascular hypertension, one with primary aldosteronism, and one with Cushing's syndrome. During the administration, the mean arterial pressure decreased concomitantly with an elevation of cardiac output and a fall in total peripheral resistance in all cases. Indicators of NO release in vivo such as plasma concentrations of L-citrulline and urinary excretion of nitrite/nitrate increased simultaneously during the administration. These results suggest that exogenous L-arginine can produce a vasodilatory effect via stimulating NO release in hypertensives.
在五名原发性高血压患者、一名肾血管性高血压患者、一名原发性醛固酮增多症患者和一名库欣综合征患者中静脉注射内皮源性舒张因子（EDRF）/一氧化氮（NO）的前体L-精氨酸。给药期间，所有病例的平均动脉压均伴随心输出量升高和总外周阻力下降而降低。给药期间，体内NO释放指标如L-瓜氨酸血浆浓度和亚硝酸盐/硝酸盐尿排泄量同时增加。这些结果表明，外源性L-精氨酸可通过刺激高血压患者体内NO释放产生血管舒张作用。
