Wride M A, Sanders E J
Department of Physiology, University of Alberta, Edmonton, Canada.
Anat Embryol (Berl). 1995 Jan;191(1):1-10. doi: 10.1007/BF00215292.
This paper reviews the evidence indicating possible roles for tumour necrosis factor-alpha (TNF alpha) in development. It is proposed that TNF alpha may have essentially three major roles during embryonic development, which may be analogous to its roles in the immune system and during inflammation: a role in programmed cell death; a role as a cellular growth and differentiation factor; and also a role in the remodelling of extracellular matrix, and the regulation of cell adhesion molecules and integrins. The concept of the existence of a cytokine array during embryogenesis, analogous to that occurring in inflammation, is discussed, as well as potential roles for TNF alpha in the induction of ubiquitin; protective mechanisms embryonic cells may employ against TNF alpha-mediated cytotoxicity; and a consideration of the role TNF alpha may play in a "free radical theory of development".
本文综述了表明肿瘤坏死因子-α（TNFα）在发育过程中可能发挥作用的证据。有人提出，TNFα在胚胎发育过程中可能主要具有三个主要作用，这可能类似于其在免疫系统和炎症过程中的作用：在程序性细胞死亡中起作用；作为细胞生长和分化因子起作用；还在细胞外基质重塑以及细胞粘附分子和整合素的调节中起作用。文中讨论了胚胎发生过程中存在类似于炎症中出现的细胞因子阵列的概念，以及TNFα在泛素诱导中的潜在作用；胚胎细胞可能采用的针对TNFα介导的细胞毒性的保护机制；并考虑了TNFα在“发育自由基理论”中可能发挥的作用。
