Hess D, Burns E, Romagnoli D, Kacmarek R M
Department of Respiratory Care, Massachusetts General Hospital, Boston 02114, USA.
Anesthesiology. 1995 Apr;82(4):903-11. doi: 10.1097/00000542-199504000-00013.
Mechanical ventilator circuits are commonly changed at 48-h intervals. This frequency may be unnecessary because ventilator-associated pneumonia often results from aspiration of pharyngeal secretions and not from the ventilator circuit. We compared the ventilator-associated pneumonia rates and costs associated with 48-h and 7-day circuit changes.
Ventilator circuits were changed at 48-h intervals during the control period (November 1992 to April 1993) and at 7-day intervals during the study period (June 1993 to November 1993). Nosocomial pneumonias were prospectively identified using the criteria of the Centers for Disease Control and Prevention. The annual cost difference of changing circuits at 48-h and 7-day intervals was calculated using the distribution of ventilator days for the control and study periods.
There were 1,708 patients, 9,858 ventilator days, and a pneumonia rate of 9.64 per 1,000 ventilator days in the control group (48-h circuit changes). There were 1,715 patients, 9,160 ventilator days, and 8.62 pneumonias per 1,000 ventilator days when circuits were changed at 1-week intervals (study group). Using a logistic regression model, there were significantly greater odds of developing a ventilator-associated pneumonia in surgical patients (odds ratio 1.77, P = 0.02) and patients in critical care units (odds ratio 1.54, P = 0.05), but no significant risk of ventilator-associated pneumonia in patients in whom circuits were changed at 1-week intervals (odds ratio 0.82, P = 0.22). Changing circuits at 7-day intervals resulted in a 76.6% ($111,530) reduction in the annual cost for materials and salaries.
We found no difference in pneumonia rates with ventilator circuit changes at 48-h and 7-day intervals. Ventilator circuits can be safely changed at weekly intervals, resulting in large cost savings.
机械通气回路通常每48小时更换一次。这种更换频率可能没有必要,因为呼吸机相关性肺炎通常是由咽部分泌物误吸引起的,而非通气回路所致。我们比较了每48小时更换通气回路和每7天更换通气回路时呼吸机相关性肺炎的发生率及成本。
在对照期(1992年11月至1993年4月)通气回路每48小时更换一次,在研究期(1993年6月至1993年11月)通气回路每7天更换一次。根据疾病控制与预防中心的标准前瞻性地识别医院获得性肺炎。利用对照期和研究期通气天数的分布情况计算每48小时和每7天更换回路的年度成本差异。
对照组(每48小时更换回路)有1708例患者,通气天数为9858天,呼吸机相关性肺炎发生率为每1000通气天数9.64例。在研究组(每1周更换回路)有1715例患者,通气天数为9160天,每1000通气天数有8.62例肺炎。使用逻辑回归模型,外科患者发生呼吸机相关性肺炎的几率显著更高(比值比1.77,P = 0.02),重症监护病房患者发生呼吸机相关性肺炎的几率也显著更高(比值比1.54,P = 0.05),但每1周更换回路的患者发生呼吸机相关性肺炎的风险无显著差异(比值比0.82,P = 0.22)。每7天更换回路使材料和人工的年度成本降低了76.6%(111,530美元)。
我们发现每48小时和每7天更换通气回路时肺炎发生率无差异。通气回路可安全地每周更换一次,从而大幅节省成本。