Zhang Z F, Vena J E, Zielezny M, Graham S, Haughey B P, Brasure J, Marshall J R
Department of Epidemiology & Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York, USA.
Arch Environ Health. 1995 Jan-Feb;50(1):13-8. doi: 10.1080/00039896.1995.9955007.
A study of 250 patients with pathologically confirmed testicular cancer diagnosed between January 1977 and June 1980 and 250 population controls matched for age and residence was carried out to investigate risk factors for testicular cancer. This paper reports results of risk associated with occupational exposure to extreme (< or = 60 degrees F or > or = 80 degrees F), high (> or = 80 degrees F), and low (< or = 60 degrees F) temperature. Interviews of approximately 1.5 h duration were conducted by trained male interviewers, using a standardized interview schedule. Mantel-Haenszel methods and logistic regression models were employed to estimate these temperature effects on risk of testicular cancer. The estimated adjusted odds ratios of testicular cancer, when 16 potential confounders were controlled for, were 1.71 (95% Cl: 1.13-2.60) for occupational exposure to extreme temperatures; 1.70 (1.04-2.78) for low temperature; and 1.20 (0.80-1.80) for high temperature. The findings suggest that occupational exposure to extreme, low, and high temperature may increase risk of testicular cancer, independent of other potential risk factors.
一项针对250例经病理确诊的睾丸癌患者（于1977年1月至1980年6月间确诊）及250名年龄和居住地相匹配的人群对照开展的研究，旨在调查睾丸癌的危险因素。本文报告了与职业性暴露于极端温度（≤60华氏度或≥80华氏度）、高温（≥80华氏度）和低温（≤60华氏度）相关的风险结果。由经过培训的男性访谈员采用标准化访谈提纲进行了约1.5小时的访谈。采用Mantel-Haenszel方法和逻辑回归模型来估计这些温度对睾丸癌风险的影响。在控制了16个潜在混杂因素后，职业性暴露于极端温度下患睾丸癌的估计调整优势比为1.71（95%置信区间：1.13 - 2.60）；低温暴露为1.70（1.04 - 2.78）；高温暴露为1.20（0.80 - 1.80）。研究结果表明，职业性暴露于极端温度、低温和高温下可能会增加患睾丸癌的风险，且独立于其他潜在风险因素。
