Wong W Y, Powars D R, Operskalski E A, Hassett J, Parker J W, Sarnaik S, Pegelow C H, Hilgartner M W, Johnson C S, Zhou Y
Department of Pediatrics, University of Southern California School of Medicine, Los Angeles 90032, USA.
Blood. 1995 Apr 15;85(8):2091-7.
Transfusions purportedly induce dysfunction of cell-mediated immunity in sickle cell anemia (SCA). We studied hematologic and lymphocytic indices in 173 human immunodeficiency virus (HIV)-negative subjects with SCA and 131 black controls. Children aged 1 to 7 years with SCA had leukocyte counts and percentages of granulocytes, monocytes, natural killer cells, and T-cell markers (CD2+CD11b+, CD4+CD26+, CD4+CD29+) that were significantly higher than those for control children. Percent total lymphocytes was decreased for this age group, but the total number of lymphocytes and T and B cell counts were similar to controls. Platelets were not increased. Adolescents (aged 8 to 17 years) and adults (aged > or = 18 years) with SCA had increased total leukocytes and monocytes and lymphocytes counts that remained level instead of decreasing, as did comparably aged controls. Lymphocyte subsets typically increased in count, but their percentage remained similar to children. The exception was CD56+ cell counts, which were increased in adolescents and adults. No lymphocytic subset change suggested impaired cellular immunity, and none could be related to transfusion. Prophylactically transfused patients had higher granulocyte counts, but these may arise from the complications of SCA itself.
据称，输血会导致镰状细胞贫血（SCA）患者的细胞介导免疫功能障碍。我们研究了173名人类免疫缺陷病毒（HIV）阴性的SCA患者和131名黑人对照者的血液学和淋巴细胞指标。1至7岁的SCA患儿的白细胞计数以及粒细胞、单核细胞、自然杀伤细胞和T细胞标志物（CD2 + CD11b +、CD4 + CD26 +、CD4 + CD29 +）的百分比显著高于对照儿童。该年龄组的总淋巴细胞百分比降低，但淋巴细胞总数以及T细胞和B细胞计数与对照组相似。血小板未增加。8至17岁的青少年和≥18岁的成年人SCA患者的白细胞、单核细胞和淋巴细胞总数增加，且保持在一定水平，而不是像年龄相仿的对照组那样减少。淋巴细胞亚群的数量通常会增加，但其百分比与儿童相似。例外的是CD56 +细胞计数，在青少年和成年人中有所增加。没有淋巴细胞亚群的变化表明细胞免疫受损，也没有任何变化与输血有关。预防性输血的患者粒细胞计数较高，但这可能是由SCA本身的并发症引起的。
