伴有原始细胞增多的难治性贫血发展为伴有白细胞血小板增多的明显白血病。

Refractory anemia with an excess of blasts developed into overt leukemia with leukothrombocytosis.

作者信息

Takahashi I, Togitani K, Yokoyama M, Aita T, Makihata K, Sunami K, Shiromoto M, Nakamura T, Kawada I, Nishimura M

机构信息

Department of Internal Medicine, Kochi Municipal Central Hospital.

出版信息

Intern Med. 1995 Jan;34(1):28-31. doi: 10.2169/internalmedicine.34.28.

DOI:10.2169/internalmedicine.34.28

PMID:7718975

Abstract

A 72-year-old man with refractory anemia with an excess of blasts developed overt leukemia with leukothrombocytosis. Hematological and physical findings closely resembled those of an accelerated or blastic phase of chronic myelocytic leukemia. The cytogenetic anomaly of i(17q) was observed during the course. The present case is suggestive of the diversities of myelodysplastic syndromes (MDS), including relationships between MDS and myeloproliferative disorders (MPD) and acute leukemia.

摘要

一名72岁患有伴原始细胞增多的难治性贫血的男性发展为伴有白细胞增多性血栓形成的明显白血病。血液学和体格检查结果与慢性粒细胞白血病加速期或急变期的表现极为相似。病程中观察到i(17q)细胞遗传学异常。本病例提示骨髓增生异常综合征（MDS）具有多样性，包括MDS与骨髓增殖性疾病（MPD）及急性白血病之间的关系。